1. （生理或智力上的）残障，残疾
    A handicap is a physical or mental disability.

    e.g. He lost his leg when he was ten, but learnt to overcome his handicap.
           他10岁时失去了一条腿，但他学会了克服自己的残疾。

2. 不利条件;障碍
    A handicap is an event or situation that places you at a disadvantage and makes it harder for you to do something.

    e.g. She was away from school for 15 weeks, a handicap she could have done without...
           她有15周没上学，这给她带来了本不该有的障碍。
    e.g. Being a foreigner was not a handicap.
           身为外国人并不是一个障碍。

3. 妨碍;使不利
    If an event or a situation handicaps someone or something, it places them at a disadvantage.

handicap

    e.g. Greater levels of stress may seriously handicap some students...
           压力的加重可能会给一些学生带来严重的负面影响。
    e.g. The industrial injuries scheme takes into account the actual disability and whether it handicaps a person in working.
           工伤赔偿方案要考虑实际残疾情况以及残疾是否会影响其工作能力。

4. （高尔夫运动中的）给弱者增加的杆数，差点
    In golf, a handicap is an advantage given to someone who is not a good player, in order to make the players more equal. As you improve, your handicap gets lower.

handicap在线翻译

    e.g. I see your handicap is down from 16 to 12.
           我发现你的差点已从16杆降到了12杆。

5. （赛马比赛的）让步赛
    In horse racing, a handicap is a race in which some competitors are given a disadvantage of extra weight in an attempt to give everyone an equal chance of winning.