We demon-strated the strategy using variants of the transcription factor LacI and operator Olac that form specifically interacting pairs . Guided by a mathematical model derived from existing quantitative knowledge , rational designs of transcriptional NAND , NOR and NOT gates have been realized .

我们利用从特异性相互作用对中挑选出的转录因子LacI及其操纵基因Olac的变体，演示如何在数学模型的辅助下，从已有的定量知识中，理性设计和实现转录的NAND，NOR和NOR门。