The marriage had broken down irretrievably by then .

到那时婚姻已无可挽回地失败了。

The local ecosystem will be irretrievably damaged if the road is built .

如果筑这条公路的话，当地的生态系统将受到无法弥补的破坏。

Is microsoft irretrievably addicted to its old-fashioned , fat client and fat license view of the world ?

微软是否已经无可救药地迷失在它过气的、大客户大许可证的世界观中了呢？

We have broken irretrievably with the past .

我们已无可挽回地与过去决裂了。

The good news is that well-established brands can take a lot of punishment before they are irretrievably damaged .

好消息是，在造成无法挽回的损失之前，知名品牌能够经受诸多惩罚。